futsch Antibody

Code CSB-PA893844XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) futsch Polyclonal antibody
Uniprot No.
Target Names
futsch
Alternative Names
futsch antibody; CG34387Microtubule-associated protein futsch antibody; MAP1B homolog) [Cleaved into: Futsch heavy chain; Futsch light chain LC(f)] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) futsch protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by Fmr1. Together with Ringer, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules.
Gene References into Functions
  1. our data are in favor of a model by which Futsch locally stabilizes synaptic active zones, by reinforcing their link with the underlying microtubule cytoskeleton. PMID: 24828631
  2. Microtubule-associated protein 1 function is fulfilled by light chain and heavy chain FUTSCH-encoded precursor polypeptide subunits, identified following proteolytic processing at a conserved cleavage site. PMID: 18419581
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton.
Tissue Specificity
Neuronal cells within the PNS and CNS.
Database Links

KEGG: dme:Dmel_CG34387

STRING: 7227.FBpp0300236

UniGene: Dm.6254

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