GAL3 Antibody

1. Computational study allowed to correctly predict that a non-synonymous SNP would change the binding affinity of Gal3p with the Gal80p transcriptional repressor. PMID: 29335276
2. The results suggest that the dynamics of residue F237 situated in the hydrophobic pocket located in the hinge region drives the transition between different conformations. PMID: 27913116
3. GAL3 is the major driver of GAL induction variation, and that GAL3 allelic variation alone can explain as much as 90% of the variation in GAL induction in a cross. PMID: 28542190
4. Discuss the effect of Gal3 on the quaternary structure of Gal80 in light of the evidence pointing to multimeric Gal80 as the form required to inhibit Gal4. PMID: 23858060
5. Overproduction of Gal3p or Gal4p mutants with altered Gal80p-binding characteristics restores GAL gene expression in mutants deficient in ATP or NADP(H) synthesis. PMID: 20979343
6. the binding of Gal3 to the Gal80 monomer competes with Gal80 self-association, reducing the amount of the Gal80 dimer available for inhibition of Gal4 PMID: 15695361
7. a conserved tyrosine in Gal3 has a role in signal transduction PMID: 16160853
8. Gal1p and Gal3p respond to their substrates in a similar, perhaps identical, fashion PMID: 16603548
9. Gal4p and Gal3p bind to Gal80p at distinct but overlapping sites PMID: 17121853
10. A reverse two-hybrid selection for GAL3 mutations that impair the Gal3-Gal80 interaction yielded 12 single-amino-acid substitutions at residues that are predicted to be surface exposed on Gal3. PMID: 18245852
11. Gal3p moves from the cytoplasm to the nucleus and interact with Gal80p in response to galactose induction. PMID: 18952899
12. A model of the structure, based on the crystal structure of the highly similar Gal1p, permits the mapping of point mutations which affect transcription activation. A model for Gal3p-Gal80p action is proposed. PMID: 16115868
13. Both MgATP and galactose are required to promote the formation of a 1:1 complex between Gal3p and Gal80p. PMID: 11964151

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KEGG: sce:YDR009W

STRING: 4932.YDR009W