gw Antibody

1. This study demonistryed that GW182's gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts the circadian neural network and its response to environmental inputs. PMID: 23583112
2. miRNA-mediated translational repression and degradation are mechanistically linked and are triggered through the interactions of GW182 with poly(A)-binding protein and deadenylases. PMID: 23172285
3. Gawky plays a critical role in miRNA-mediated gene silencing. (Review) PMID: 23224968
4. MicroRNAs utilize at least three distinct silencing pathways: GW182-mediated deadenylation and GW182-dependent and -independent repression of early translation initiation. PMID: 23123195
5. Data demonstrate that in human and Drosophila melanogaster cells, the critical repressive features of both the N-terminal and C-terminal effector domains of GW182 proteins are Gly/Ser/Thr-Trp (G/S/TW) or Trp-Gly/Ser/Thr (WG/S/T) motifs. PMID: 21984184
6. Multiple GW/WG repeats present in the minimal N-terminal repressor domain of Drosophila GW182 are required for target mRNA repression. PMID: 20530530
7. GW182 links the miRNA pathway to mRNA degradation PMID: 16815998
8. This suggests that gawky represents a previously unknown member of a small group of genes that need to be expressed zygotically during early embryo development. PMID: 16880270
9. deletion of the RNA recognition motif impairs the silencing activity of GW182 in a miRNA target-specific manner, indicating that this domain contributes to silencing. PMID: 19295135
10. Using both tethered function and complementation assays, study identified 3 independent domains of the Drosophila GW182 protein (also termed Gawky) that are sufficient to repress mRNA. PMID: 19304924

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KEGG: dme:Dmel_CG31992

STRING: 7227.FBpp0088165

UniGene: Dm.1403