rack-1 Antibody

Code CSB-PA635346XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans rack-1 Polyclonal antibody
Uniprot No.
Target Names
rack-1
Alternative Names
rack-1 antibody; K04D7.1Guanine nucleotide-binding protein subunit beta-2-like 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans rack-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.
Gene References into Functions
  1. this study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against Shigella flexneri infection PMID: 28502651
  2. Lactobacillus casei pretreatment triggers the TLR mediated and rack-1 dependent p38 MAPK signaling pathway in nematodes. rack-1 is necessary in activating the p38 MAPK pathway by Lactobacillus casei. PMID: 27338631
  3. RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development. PMID: 24776851
  4. RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression. PMID: 21525958
  5. show that depletion of Caenorhabditis elegans RACK-1, which leads to short astral microtubules during prometaphase, specifically affects maintenance of cortical PAR domains and Dynamin localization PMID: 21533050
  6. These studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac GTPases and UNC-115/abLIM. PMID: 21124943
  7. suggest a mechanism by which RACK-1 directs the dynactin-dependent redistribution of recycling endosomes during the cell cycle PMID: 19158384

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Protein Families
WD repeat G protein beta family, Ribosomal protein RACK1 subfamily
Database Links

KEGG: cel:CELE_K04D7.1

STRING: 6239.K04D7.1.4

UniGene: Cel.4889

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