Gen Antibody

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Code	CSB-PA894726XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Gen Polyclonal antibody

Uniprot No.

Q9VRJ0

Target Names

Gen

Alternative Names

Gen antibody; CG10670Flap endonuclease GEN antibody; EC 3.1.-.- antibody; Flap structure-specific endonuclease GEN antibody; Xpg-like endonuclease antibody; DmGEN antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Gen protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates.

Gene References into Functions

the in vitro activities of DmGen and HsGEN1 are strikingly similar. PMID: 28369583
Cloning and characterization of DmGEN, Drosophila Melanogaster XPG-like endonuclease, a RAD2 nuclease family member. PMID: 15576351
DmGEN belongs to a new class (class IV) of the RAD2/XPG nuclease family PMID: 17614965

Subcellular Location

Nucleus.

Protein Families

XPG/RAD2 endonuclease family, GEN subfamily

Database Links

KEGG: dme:Dmel_CG10670

STRING: 7227.FBpp0076879

UniGene: Dm.847

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