GIGYF2 Antibody

1. Full-length GIGYF2 coimmunoprecipitates with AGO2 in human cells, and upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression. PMID: 27157137
2. required, this finding may shed light on the GIGYF2-associated mechanisms that lead to PD and suggests insulin dysregulation as a disease-specific mechanism for both PD and cognitive dysfunction. PMID: 26134514
3. Results suggest that the N56S and N457T of GIGYF2 are risk factors for Parkinson's disease in Caucasians, but not in Asians PMID: 26152800
4. GIGYF2 and the zinc finger protein 598 (ZNF598) are identified as components of the 4EHP complex. PMID: 22751931
5. Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease PMID: 22503729
6. within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing Parkinson disease. PMID: 22115759
7. These data, together with those recently reported by other groups, suggest that GIGYF2 is unlikely to be the PARK11 gene. PMID: 20060621
8. No clearly pathogenic mutations are identified in GIGYF2 and ATP13A2 in Brazilian patients with early-onset Parkinson's disease. PMID: 20816920
9. The results of this study did not support a role for GIGYF2 in the genetic etiology of Belgian Parkinson disease. PMID: 19321232
10. GIGYF2 is unlikely to play a major role in PD in Japanese patients, similar to other populations. PMID: 20641165
11. our findings suggest that GIGYF2 variants are not a frequent cause of Parkinson's disease in the Spanish population, since we found no clearly segregating GIGYF2 variants PMID: 19845746
12. GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese Population. PMID: 20044296
13. The results of this study do not support a major role of GIGYF2 in parkinson disease. PMID: 20004041
14. We identified nine novel variants in GIGYF2 gene, which might be associated with PD in the Chinese population. PMID: 20178831
15. These data strongly support GIGYF2 as a PARK11 gene with a causal role in familial Parkinson disease. PMID: 18358451
16. Mutations in GIGYF2 are not strongly related to the development of the Parkinson's disease in Portuguese and North American populations. PMID: 18923002
17. This study suggested that reported mutations in GIGYF2 are not a common cause of Parkinson's disease in Norway and United States. PMID: 19133664
18. The results of this study concluded that neither of Asn56Ser and Asn457Thr variants plays a major role in the pathogenesis of parkinson disease. PMID: 19250854
19. We believe that variation in a gene other than GIGYF2 accounts for the previously reported linkage finding on chromosome 2q36-37. PMID: 19279319
20. The current genetic evidence suggestes that GIGYF2 is not a common cause od parkinson disease in several Caucasian. PMID: 19348706
21. GIGYF2 Asn56Ser and Asn457Thr mutations are a rare cause of PD in North American Caucasian population PMID: 19429085
22. analysis of GIGYF2 variants in Parkinson's disease from two Asian populations PMID: 19449032
23. GIGYF2 mutations are not a frequent cause of Parkinson's disease PMID: 19482505
24. This letter suggested that GIGYF2 is neither responsible for PARK11 nor a gene implicated in Parkinson disease. PMID: 19562763
25. The GIGYF2 Asn56Ser mutation is rare in Chinese PD patients. PMID: 19638301

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HGNC: 11960

OMIM: 607688

KEGG: hsa:26058

STRING: 9606.ENSP00000387170

UniGene: Hs.565319