Gr43a Antibody

Code CSB-PA895567XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Gr43a Polyclonal antibody
Uniprot No.
Target Names
Gr43a
Alternative Names
Gr43a; GR43.1; CG1712; Gustatory receptor for sugar taste 43a
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Gr43a protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies.
Gene References into Functions
  1. Here we sought to decipher the genes required for fructose response among Gr64a-Gr64f genes. Unexpectedly, the qPCR analyses for these genes show that labellar expression levels of Gr64d and Gr64e are higher in fructose low-sensitivity flies than in high-sensitivity flies PMID: 29047261
  2. Gr43a is the main receptor for larval sugar preference.Late sugars preference is mediated by Gr43a-expressing brain neurons. PMID: 23850280
  3. Studies indicate that the Gr43a-expressing brain neurons function as a nutrient sensor for hemolymph fructose and assign opposing valence to feeding experiences in a satiation-dependent manner. PMID: 23178127
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Insect chemoreceptor superfamily, Gustatory receptor (GR) family, Gr21a subfamily
Tissue Specificity
Expressed in the adult labellar chemosensory neurons and in the adult head, abdomen, leg and wing. In larvae, is expressed in taste organs, as well as the brain and the gastrointestinal system.
Database Links

KEGG: dme:Dmel_CG1712

STRING: 7227.FBpp0110117

UniGene: Dm.26868

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