Gr68a Antibody

Code CSB-PA893802XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Gr68a Polyclonal antibody
Uniprot No.
Target Names
Gr68a
Alternative Names
Gr68a; GR68D.1; CG7303; Gustatory receptor 68a
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Gr68a protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the release of the neuropeptide tachykinin from a cluster of 8-10 neurons in the SEZ.
Gene References into Functions
  1. This study constructed a receptor-to-sensillum map of the legs and a receptor-to-neuron map. PMID: 24849350
  2. GR68a protein recognizes a female pheromone(s) involved in the second step of the courtship display, which is essential for efficient execution of the entire courtship and timely mating. PMID: 12971900
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Insect chemoreceptor superfamily, Gustatory receptor (GR) family, Gr21a subfamily
Tissue Specificity
Expressed in chemosensory neurons of about 20 male-specific gustatory bristles in the forelegs. No expression is seen in the mechanosensory neurons. In larvae, expressed in the ventral pharyngeal sense organ.
Database Links

KEGG: dme:Dmel_CG7303

STRING: 7227.FBpp0075849

UniGene: Dm.27850

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