GRE2 Antibody

Datasheet

Code	CSB-PA609123XA01SVG
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: GRE2 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 30 kDa Observed band size: 30 kDa
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Target Background

Product Details

Uniprot No.

Q12068

Target Names

GRE2

Alternative Names

NADPH-dependent methylglyoxal reductase GRE2 (EC 1.1.1.283) (3-methylbutanal reductase) (EC 1.1.1.265) (Genes de respuesta a estres protein 2) (Isovaleraldehyde reductase) GRE2 YOL151W

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) GRE2 protein (1-120aa)

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The generation of polyclonal antibodies against GRE2 includes iterative immunizations of a rabbit using recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) GRE2 protein (1-120aa). Following the attainment of a satisfactory antibody titer, the rabbit undergoes bleeding, and antibodies are isolated from the serum and then purified using affinity chromatography. The efficacy of the GRE2 antibody is assessed through ELISA and WB applications, demonstrating reactivity with Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) GRE2 protein.

The Saccharomyces cerevisiae GRE2 plays an essential role in cellular metabolism and detoxification processes. Possessing NADPH-dependent oxidoreductase activity, GRE2 contributes to cellular redox balance, maintaining homeostasis by participating in electron transfer reactions. Notably, GRE2 is involved in the detoxification of various compounds, particularly aldehydes and reactive intermediates, playing a protective role in shielding the cell from potential damage.

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Target Background

Function

Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation. Also catalyzes the reduction of 3-methylbutanal to 3-methylbutanol. Acts as a suppressor of 3-methylbutanol-induced filamentation by modulating the levels of 3-methylbutanal, the signal to which cells respond by filamentation. Also involved in ergosterol metabolism.

Gene References into Functions

Gre2 forms a homodimer, each subunit of which contains an N-terminal Rossmann-fold domain and a variable C-terminal domain, which participates in substrate recognition. PMID: 24879127
In spite of the monomeric nature of Gre2p in solution, packing and self-rotation calculations revealed the existence of two Gre2p protomers per asymmetric unit related by a twofold noncrystallographic axis. PMID: 20606287
GRE2 is involved in ergosterol metabolism in Saccharomyces cerevisiae and significantly effects growth. PMID: 16598690
These results indicate a previously unsuspected and novel role for the GRE2 gene product as a suppressor of filamentation by virtue of encoding isovaleraldehyde reductase activity. PMID: 16999827

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

NAD(P)-dependent epimerase/dehydratase family, Dihydroflavonol-4-reductase subfamily

Database Links

KEGG: sce:YOL151W

STRING: 4932.YOL151W

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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GRE2 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background