GUK1 Antibody

Code CSB-PA619089ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GUK1 Polyclonal antibody
Uniprot No.
Target Names
GUK1
Alternative Names
ATP:GMP phosphotransferase antibody; FLJ42686 antibody; FLJ43710 antibody; GMK antibody; GMP kinase antibody; Guanylate kinase antibody; GUK1 antibody; KGUA_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens GUK1 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine.
Gene References into Functions
  1. HGS and GUK1 were significantly over expressed in GH-secreting adenomas, compared with ACTH-secreting adenomas and nonfunctioning tumors, and with PRL-secreting adenomas, respectively. PMID: 16832584
Subcellular Location
Photoreceptor inner segment. Cytoplasm, cytosol.
Protein Families
Guanylate kinase family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 4693

OMIM: 139270

KEGG: hsa:2987

STRING: 9606.ENSP00000355689

UniGene: Hs.376933

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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