HHO1 Antibody

1. data suggest that complete absence of Hho1 from chromatin does not affect reciprocal recombination between homologous chromosomes during meiosis PMID: 26122007
2. deletion of HHO1 gene in S. cerevisiae leads to alterations in the higher-order levels of chromatin organization. PMID: 22200500
3. Hho1 may play a dual role during sporulation: Hho1 and Ume6 depletion facilitates the onset of meiosis via activation of Ume6-repressed early meiotic genes, whereas Hho1 enrichment in mature spores contributes to spore genome compaction. PMID: 22586276
4. findings demonstrated that the two globular domains independently associated with two different four-way junction molecules in a manner that required amino acid residues implicated in structure-specific binding in the nucleosome PMID: 16342967
5. Hho1p reinforces the action of several types of barrier elements, and also inhibits silencing on its own. PMID: 16582449
6. results suggest that histone H1 represses recombination at the rDNA by a mechanism that is independent of the recombination pathways regulated by Sir2 PMID: 18179596
7. Hho1p is involved in rDNA compaction, and like core histones, is required for efficient rDNA transcription by pol I PMID: 18687885
8. Hho1p has a limited role in transcriptional regulation; this dynamically exchanging linker histone may be evicted from chromatin by transcriptional activity. PMID: 18799740
9. mode of Hho1p action is similar to that of canonical linker histones PMID: 19017647

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KEGG: sce:YPL127C

STRING: 4932.YPL127C