h Antibody

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Code	CSB-PA318457XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) h Polyclonal antibody

Uniprot No.

P14003

Target Names

Alternative Names

h antibody; CG6494Protein hairy antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) h protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Pair-rule protein that regulates embryonic segmentation and adult bristle patterning. Transcriptional repressor of genes that require a bHLH protein for their transcription (e.g. ftz).

Gene References into Functions

Hairy induces widespread histone deacetylation and inhibits the recruitment of basal machinery without inducing chromatin compaction. PMID: 21353562
In this study, the authors show that Dgrn is a negative regulator of the repressor Hairy and its corepressor Groucho (Gro/transducin-like enhancer (TLE)) during embryonic segmentation and neurogenesis. PMID: 21343912
Studies demonstrate a novel role for Hairy in restriction of the terminal cell fate by limiting the domain of bnl expression in surrounding muscle cells such that only a single dorsal branch cell becomes specified as a terminal cell. PMID: 21152432
identification as a quantitative trait locus for drosophila sensory bristle number PMID: 12242230
Data show that a 121-nucleotide element within the 3'-untranslated region of hairy is necessary and sufficient to mediate apical transport. PMID: 12743042
Hairy and Dl function concertedly and nonredundantly to define periodic proneural gene achaete expression. PMID: 16542648
long-range effects may be mediated by a "spreading" mechanism, modifying chromatin over extensive regions to inhibit transcription PMID: 18285466
These studies suggest that protein kinase CK2 contributes to repression by Hairy. PMID: 18601910
hypoxia-selected flies: (a) altered their gene expression and genetic code, and (b) coordinated their metabolic suppression, especially during development, with hairy acting as a metabolic switch, thus playing a crucial role in hypoxia-tolerance PMID: 18927626

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Subcellular Location

Nucleus.

Database Links

KEGG: dme:Dmel_CG6494

STRING: 7227.FBpp0099504

UniGene: Dm.2554

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