Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Hip1 Polyclonal antibody

Uniprot No.

Q8VD75

Target Names

Hip1

Alternative Names

Hip1 antibody; Kiaa4113Huntingtin-interacting protein 1 antibody; HIP-1 antibody; Huntingtin-interacting protein I antibody; HIP-I antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Hip1 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Gene References into Functions

we show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase, Hip1. PMID: 24659689
HIP1 association with and phosphorylation mediated by EGFR and EGFRvIII. PMID: 23836884
Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit PMID: 21697888
Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathw PMID: 11788820
HIP1 is the first endocytic protein to be directly implicated in tumor formation PMID: 12781365
disuprtion results in neurological deficits and decreased AMPA receptor trafficking PMID: 12839988
three different mutations lead to hematopoietic abnormalities reflected by diminished early progenitor frequencies PMID: 14998932
mice deficient in both HIP1 and HIP1r have accelerated development of abnormalities seen in Hip1 -deficient mice, including kypholordosis and growth defects PMID: 15121852
The various abnormalities corroborate reduced fertility levels in HIP1(-/-) mice and suggest a role for HIP1 in stabilizing actin and microtubules, enabling normal spermatid and Sertoli cell morphology and function. PMID: 16967501
we have shown that HIP1 influences important NMDAR functions and that both HIP1 and htt participate in NMDA-induced cell death. PMID: 17329427
Degenerative phenotypes seen in knockout mice are due mainly to HIP1 and HIP1r protein deficiency rather than altered expression of neighboring genes or disrupted intronic elements. PMID: 17452370
Presynaptic function is altered in hippocampal brain slices of HIP1-deficient mice demonstrating delayed recovery from synaptic depression and a reduction in paired-pulse facilitation. PMID: 17928447
The presence of a 110-kDa form of HIP1 in tumor cells was discovered. Upon sequencing of Hip1 DNA and message from these tumors, it was seen that this 110-kDa form of HIP1 is the product of splicing of a cryptic U12-type AT-AC intron. PMID: 18281481
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740

Hide All

Subcellular Location

Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane.

Protein Families

SLA2 family

Tissue Specificity

Most abundantly expressed in brain. In brain, expressed in cortical tissue, hippocampus, the molecular layer of the cerebellum and olfactory bulb. Also expressed in spinal cord and bone marrow (at protein level). Expressed in reproductive tissues.

Database Links

KEGG: mmu:215114

STRING: 10090.ENSMUSP00000059033

UniGene: Mm.280805

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Hip1 Antibody

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