HIP1

HIP1, a membrane-bound protein, is distributed across several tissues, including the brain and lungs. HIP1 protein is crucial for clathrin-mediated endocytosis, a process essential for bringing substances into the cell. It also plays a key role in the intra-cellular transport of proteins. Additionally, HIP1 binds to the protein involved in Huntington's disease; however, this interaction is absent in patients with the disease. HIP1 is also involved in the regulation of critical cellular activities, including proliferation, apoptosis, migration, and invasion. Its misexpression has been implicated in the development and progression of various cancers, influencing tumor behavior and patient outcomes. Research indicates that HIP1 is overexpressed in a variety of human cancers, pointing to its possible role in the carcinogenic process.