hiw Antibody

1. Results indicate that the ability of faf, hiw or Rdl to modulate sleep and protect against cognitive impairments during waking is circuit dependent. Decreasing hiw and Rdl within the Mushroom Bodies protects against the negative effects of sleep deprivation as indicated by the absence of a subsequent homeostatic response, or deficits in short-term memory. PMID: 29109678
2. Highwire promotes axon termination, pruning and synaptogenesis. PMID: 28100586
3. The dual leucine zipper kinase (DLK) signaling pathway in Drosophila, which consists of Highwire and Wallenda and controls axonal growth, regeneration, and degeneration, is also involved in dendritic growth in vivo. PMID: 23750116
4. An increased level of Nmnat protein in hiw mutants is both required and sufficient to inhibit axonal degeneration. PMID: 23226106
5. Genetic interaction studies suggest that Highwire and Plexin A signals may interact to regulate normal morphogenesis of alpha/beta axons. PMID: 22131429
6. The regulation of Wnd protein turnover by Hiw can function as a damage surveillance mechanism for responding to axonal injury. PMID: 20921142
7. BMP signaling mutants suppress the excessive synaptic growth in Highwire mutants. Activation of BMP signaling in Highwire mutants causes further synaptic expansion. PMID: 15046722
8. Highwire may independently regulate the molecular pathways controlling synaptic growth and function. PMID: 16237161
9. These results suggest that Highwire controls structural plasticity of the synapse by regulating gene expression through a MAP kinase signaling pathway. PMID: 16815332

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KEGG: dme:Dmel_CG32592

STRING: 7227.FBpp0073787