hlh-11 Antibody

Code CSB-PA330359XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans hlh-11 Polyclonal antibody
Uniprot No.
Target Names
hlh-11
Alternative Names
hlh-11 antibody; F58A4.7 antibody; Helix-loop-helix protein 11 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans hlh-11 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Transcriptional regulator. Component of a feedback loop involving atfs-1, atgl-1 and hlh-11. Binds to the promoter of the atgl-1 lipase to negatively regulate the expression of atgl-1, and thereby promoting fat oxidation in response to mitochondrial stress and mitochondrial respiration in the intestine. In addition, functions with atfs-1 to maintain lifespan. May have a role in fertility and in positively regulating body size.
Gene References into Functions
  1. hlh-11 may function to regulate serotonin-mediated egg laying at the downstream of tax-6. PMID: 19855932
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in the pharynx, nerve cords, the H-shaped excretory cell, vulva muscles, and the anal depressor (at protein level). Expressed in the intestine (at protein level). In males, it is also expressed in the spicules and hyp7 cells of the hypodermis (a
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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