HMA4 Antibody

1. To test whether developing Arabidopsis seeds depend on AtHMA2 and AtHMA4 for proper zinc unloading from the seed coat, the authors analysed the amount of zinc present in the maternal and filial parts of the seed, respectively, in wild-type and mutant seeds lacking functional AtHMA2, AtHMA4, or both. PMID: 27243644
2. overexpression modulates the ratio of Zn to Cd supply as a determinant of metal-homeostasis gene expression in tobacco PMID: 27811086
3. These studies evaluated the the function and structure of the N-terminal cytoplasmic metal-binding domain of HMA4. PMID: 26797794
4. Due to ectopic expression of 35S::AtHMA4, the physical apoplastic barrier within the external cell layer developed, which is likely to be responsible for the reduction of Cd uptake/accumulation. PMID: 24420575
5. Ectopically expressing AtHMA4 in tobacco results in overloading the root and leaf apoplast with zinc. PMID: 23170996
6. the C-terminal domain of AtHMA4 serves a dual role as Zn(2+) and Cd(2+) chelator (sensor) and as a regulator of the efficiency of Zn(2+) and Cd(2+) export. PMID: 20650903
7. The binding affinities of HMA2 and HMA4 for zinc are higher than that of HMA7 by a factor of 20-30, but the relative affinities for copper are inverted by a factor of 30-50. PMID: 19883117
8. AtHMA4 overexpressing lines displayed an increase in the zinc and cadmium content of shoots. [AtHMA4] PMID: 15498553
9. Mutagenesis of the cysteine and glutamate residues from the N-ter degenerated heavy metal binding domain impaired the function of AtHMA4 [HMA4] PMID: 15733866
10. The near-complete abolition of root-to-shoot Cd translocation resulting from the loss of function of HMA2 and HMA4 demonstrates they are the major mechanism for Cd translocation in Arabidopsis thaliana. PMID: 19076718

Show More

Hide All

KEGG: ath:AT2G19110

STRING: 3702.AT2G19110.1

UniGene: At.25023