en Antibody

1. Data show that the Distalless and Engrailed homeodomain transcription factors act through sequences in this enhancer to establish elevated Sex combs reduced (Scr) expression in spatially defined domains. PMID: 29634724
2. these results suggest that En in Johnston's Organ neurons regulate both neuronal excitability and synaptic connectivity. PMID: 25164665
3. Silencing Engrailedin Johnston's organ neurons reduces the sound-evoked potential amplitude at the onset of the stimulus by about half at 100, 200 and 400 Hz. PMID: 23940751
4. This study showed that small subset of FRUM neurons distributed in the brain and ventral cord of males by their co-expression with in En neurons PMID: 23688386
5. Our studies identified several abnormal phenotypes in live engrailed (en) mutant embryos prior to cycle 8. Nuclei in en embryos divide asynchronously, an abnormality that was detected as early as nuclear cycle 2-3. PMID: 23593026
6. Polycomb group protein binding per se does not determine the transcriptional state of engrailed. PMID: 23139817
7. During development of the Drosophila ocellar complex, engrailed (en) plays a role both as a target and as a transcriptional repressor of hedgehog (hh) signaling in the prospective interocellar region. PMID: 23154412
8. Anterior crossvein formation requires En function. An extracellular pool of En protein is present in the wing disc that diffuses beyond its expression domain and is required for the formation of the anterior crossvein. PMID: 21558379
9. Data suggests that engrailed folds to its native structure via an intermediate in which the HTH motif is formed, and that secondary structure development occurs first followed by tertiary packing. PMID: 21035367
10. Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord PMID: 20673828
11. high levels of Engrailed make the epidermal cells inhospitable to bristle neurons; sensory axons that are too near these cells are either deflected or fail to extend properly or at all PMID: 20667917
12. electrostatics significantly affect the stability of designed homeodomain variants PMID: 11829512
13. relationship between engrailed and dominant additional vein mutant PMID: 12502252
14. En is a bifunctional transcription factor and the recruitment of additional cofactors presumably specifies which function prevails on an individual promoter. PMID: 12506003
15. Folding pathway of the three-helix bundle protein Engrailed homeodomain PMID: 12594518
16. crystal structures of engrailed homeodomain mutants PMID: 12923178
17. Engrailed is responsible for the establishment of ci repression early during embryonic development and is also required to maintain the repression of ci throughout development. PMID: 15282166
18. Engrailed's function during the segregation of the neuroblasts is crucial for regulating different actors that are later involved in axon guidance PMID: 17126316
19. compartmental expression of Ubx and abd-A is established through a repressive regulatory network between en, slp, Ubx and abd-A PMID: 17573068
20. Engrailed Polycomb-group response elements bring chromatin together, allowing both positive and negative regulatory interactions between distantly located DNA fragments. PMID: 18199580
21. Molecular dynamics simulations were performed on an ultrafast unfolding and folding protein at its melting temperature to observe, on an atom-by-atom basis, the pathways the protein followed as it unfolded and folded within a continuous trajectory. PMID: 18553935
22. Engrailed expression in subsets of adult Drosophila sensory neurons. PMID: 18597129
23. Using a Drosophila model of Huntington's disease, we found that Engrailed (EN), a transcriptional activator of endogenous Drosophila htt (dhtt), is able to prevent aggregation of polyQ-hHtt. PMID: 18718937
24. en expression is down-regulated in the posterior portion of wing discs, indicating that the PRC2 complex acts as an activator of en. PMID: 19368801
25. Data show that engrailed enhancers can act over large distances, even skipping over other transcription units, choosing the engrailed promoter over those of neighboring genes. PMID: 19675130

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KEGG: dme:Dmel_CG9015

STRING: 7227.FBpp0087197

UniGene: Dm.22056