how Antibody

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Code	CSB-PA517286XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) how Polyclonal antibody

Uniprot No.

O01367

Target Names

how

Alternative Names

how antibody; KH93F antibody; qkr93F antibody; stru antibody; who antibody; CG10293 antibody; Protein held out wings antibody; KH domain protein KH93F antibody; Protein muscle-specific antibody; Protein struthio antibody; Protein wings held out antibody; Putative RNA-binding protein antibody; Quaking-related 93F antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) how protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Required for integrin-mediated cell-adhesion in wing blade. Vital role in steroid regulation of muscle development and to control heart rate. Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization.

Gene References into Functions

Spatiotemporal regulation of HOW expression is required to specify the four spermatogonial transit-amplifying divisions. PMID: 20362539
MAPK/ERK-dependent phosphorylation of HOW promotes the formation of HOW dimers and thus enhances its activity in controlling mRNA levels of key muscle-specific genes PMID: 22479211
HOW has different roles in male and female Drosophila germline differentiation PMID: 22163028
isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation PMID: 11832244
Cell divisions in the drosophila embryonic mesoderm are repressed via posttranscriptional regulation of string/cdc25 by Held Out Wing protein. PMID: 15723789
Four mRNAs were found to be specifically elevated in the mesoderm of how germline clone embryos, and to exhibit specific binding to HOW via their 3' UTRs. PMID: 17728343

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Subcellular Location

Nucleus.

Tissue Specificity

During embryogenesis, expression is seen in mesodermal precursors of somatic, visceral and pharyngeal muscle. Later in embryogenesis, expression is restricted to heart and muscle attachment sites of the epidermis. During onset of metamorphosis, expression

Database Links

KEGG: dme:Dmel_CG10293

STRING: 7227.FBpp0083575

UniGene: Dm.20227

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