Hr4 Antibody

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Code	CSB-PA895239XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Hr4 Polyclonal antibody

Uniprot No.

Q9W539

Target Names

Hr4

Alternative Names

Hr4 antibody; NR6A2 antibody; CG43934 antibody; Hormone receptor 4 antibody; dHR4 antibody; Nuclear receptor subfamily 6 group A member 2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Hr4 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor.

Gene References into Functions

DHR3 and Hr4 gene expression is dose dependent, is completely controlled by the hormone titer and decreases within hours of 20-hydroxyecdysone withdrawal. PMID: 26506480
Following the onset of zygotic gene expression, Slam and Nullo together stabilise the retracting metaphase furrow and Slam triggers invagination of the cleavage furrow. PMID: 24368071
Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development PMID: 21980261
Results show that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone. PMID: 19237466

Subcellular Location

Nucleus.

Protein Families

Nuclear hormone receptor family, NR1 subfamily

Tissue Specificity

During L2 and L3 stages, strong constitutive expression is seen in the ring gland. Lower expression is detected in specific neurons of the central nervous system (CNS) (at protein level).

Database Links

KEGG: dme:Dmel_CG43934

STRING: 7227.FBpp0305535

UniGene: Dm.17760

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Gene Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Hr4 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background