Ica1 Antibody

Datasheet

Code	CSB-PA010947XA01MO
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Ica1 Polyclonal antibody

Uniprot No.

P97411

Target Names

Ica1

Alternative Names

Ica1 antibody; Icap69 antibody; Islet cell autoantigen 1 antibody; 69 kDa islet cell autoantigen antibody; ICA69 antibody; Islet cell autoantigen p69 antibody; ICAp69 antibody; p69 antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Ica1 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

May play a role in neurotransmitter secretion.

Gene References into Functions

ICA69 deficiency promoted formalin-induced long-lasting pain hypersensitivity. PMID: 25547463
direct link between compromised thymic ICA69 expression and autoimmunity against multiple ICA69-expressing organs, and identify a potential novel mechanism for the development of multi-organ autoimmune diseases. PMID: 25088457
C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity. PMID: 24358315
PICK1 and ICA69 are key regulators of the formation and maturation of insulin granules. PMID: 23630453
polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells. PMID: 22447927
ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide PMID: 11751995

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Subcellular Location

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

Tissue Specificity

Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis.

Database Links

KEGG: mmu:15893

STRING: 10090.ENSMUSP00000040062

UniGene: Mm.275683

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Ica1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background