infB Antibody

1. IF2 and unique features of initiator tRNA(fMet) help establish the translational reading frame. PMID: 28914580
2. MD simulations of IF2 docked onto the L12-CTD pinpointed the exact interacting partners-all of which were positively charged on L12 and negatively charged on IF2, connected by salt bridges. PMID: 29686090
3. The structural transitions of IF2 C-terminal upon GDPNP binding and following nucleotide hydrolysis support the concept of cofactor-dependent conformational switching rather than the classical model for GTPase activity. PMID: 21988058
4. Rapid docking of 30S with 50S subunits in initiation of translation depends on switching 30S subunit-bound IF2 from its inactive to active form. PMID: 21151095
5. The authors provide evidence that mutant IF2 specifically interacts with rpsL31 in cold, leading to a bacteriostatic effect on host cells. PMID: 19716413
6. IF2alpha and IF2beta display almost indistinguishable properties, whereas IF2DeltaN, displays functional activities having properties and requirements distinctly different from those of the intact molecule. PMID: 16935296
7. Data show that translational initiation factor 2 (IF2) binds ppGpp at the same site and with similar affinity as GTP, and suggest that GTP and the alarmone ppGpp can be considered two alternative physiologically relevant IF2 ligands. PMID: 16968770
8. Overexpression of IF2 or increasing the affinity of mutant initiator tRNA for IF2 enhanced re-initiation efficiency, suggesting that IF2 is required for efficient re-initiation. PMID: 18221266
9. Data show that initiation factor 2 ameliorated the growth and polysome defects of the delta yjeQ strain. PMID: 18223068

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KEGG: ecj:JW3137

STRING: 316385.ECDH10B_3342