mua-6 Antibody

Code CSB-PA522331XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mua-6 Polyclonal antibody
Uniprot No.
Target Names
mua-6
Alternative Names
mua-6 antibody; ifa-2 antibody; W10G6.3Intermediate filament protein ifa-2 antibody; Cel IF A2 antibody; Intermediate filament protein A2 antibody; IF-A2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mua-6 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.
Gene References into Functions
  1. Results suggest that the head domain contains redundant signals for IF localization, whereas non-redundant essential functions map to the IFA-2 tail, although the tail is unlikely to be directly involved in fibrous organelle localization. PMID: 25742641
Subcellular Location
Cell junction, hemidesmosome. Note=Colocalizes with myoactin.
Protein Families
Intermediate filament family
Tissue Specificity
Mainly expressed in regions of the hypodermis adjacent to muscle. Expressed in longitudinal stripes where the mechanosensory neurons interface with the hypodermis. Also expressed to the uterine seam and within the uterine-vulval cells.
Database Links

KEGG: cel:CELE_W10G6.3

STRING: 6239.W10G6.3.2

UniGene: Cel.17660

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