ihog Antibody

Code CSB-PA895632XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) ihog Polyclonal antibody
Uniprot No.
Target Names
ihog
Alternative Names
ihog antibody; CG9211Interference hedgehog antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) ihog protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
Gene References into Functions
  1. Hh and its co-receptor Ihog are in exovesicles transported via cytonemes. Hh transport via exosomes along cytonemes is a significant mechanism for the restricted distribution of a lipid-modified morphogen. PMID: 25472772
  2. A functional interaction between Ihog and members of the Shf/WIF1 family demonstrates that Ihog can increase the Wnt-inhibitory activity of vertebrate WIF1. PMID: 23154411
  3. Data show that Dispatched could be involved in the regulation of vesicular trafficking necessary for basolateral release of Hh, Dlp, and Ihog. PMID: 21690386
  4. Results describe the interaction of interference hedgehog with Hedgehog ligands via a specific fibronectin III domain. PMID: 16630821
  5. Hedgehog directly binds Ihog and provide the first demonstration of a specific role for heparin in Hedgehog responsiveness PMID: 17077139

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, IHOG family
Database Links

KEGG: dme:Dmel_CG9211

STRING: 7227.FBpp0078993

UniGene: Dm.11441

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