KAP123 Antibody

Datasheet

Code	CSB-PA336672XA01SVG
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: KAP123 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 28 kDa Observed band size: 28 kDa
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Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) KAP123 Polyclonal antibody

Uniprot No.

P40069

Target Names

KAP123

Alternative Names

Importin subunit beta-4 (Importin-123) (Karyopherin subunit beta-4) (Karyopherin-123) (Ran-binding protein YRB4) KAP123 YRB4 YER110C

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (Baker's yeast) KAP123 protein (859-1110aa)

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins. Required for import of the ribosomal assembly factor NMD3. May be involved in nuclear transport of YAP1. Mediates the nuclear import of histones H3 and H4. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene References into Functions

The karyopherin Kap123 binds to a nuclear localization sequence next to this amphipathic alpha-helix and prevents unspecific tethering of Nbp1 to membranes. PMID: 21785410
Slt2, the mitogen-activated protein kinase of the protein kinase C cell integrity pathway, is constitutively activated in the absence of Kap123, which is consistent with the existence of cell integrity defects. PMID: 19930464
A role for the karyopherin Kap123p in microtubule stability is reported. PMID: 19761543
The Kap123p specifically binds to histones H2A and H2B. PMID: 15679097

Subcellular Location

Cytoplasm. Nucleus. Nucleus, nuclear pore complex.

Protein Families

Importin beta family

Database Links

KEGG: sce:YER110C

STRING: 4932.YER110C

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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KAP123 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background