IME2 Antibody

1. identify the protein kinase Ime2 to bring about Rim4 clearance via phosphorylation of Rim4's intrinsically disordered region PMID: 29738715
2. Here we show that Ime2 activity is required to induce the translation of SSP2 mRNA at anaphase II PMID: 26246597
3. Positive auto-regulation of Ime2 produces a bistable system with a normal meiotic state and a more efficient meiotic state. PMID: 23631506
4. The ectope expression of Ime2 has deterious on cell cycle regulation, toxocity and the response of the DNA damage checkpoint. PMID: 21099355
5. Epistasis analysis suggests that Ime1 and Ime2 act in the same order in pseudohyphal growth as in meiosis. PMID: 20876298
6. SCFGrr1p-dependent destruction of Ime2p kinase has a role in glucose inhibition of meiotic DNA replication PMID: 15601864
7. Rfa2 serine 27 (S27) is required for Ime2-dependent Rfa2 phosphorylation in vivo. PMID: 16294044
8. plays a role in controlling the exit from meiosis I and a phospho-modification pathway regulates Ime2p during the different phases of meiotic development PMID: 16684773
9. Histone deacetylase plays a role in regulating the timing of IME2 expression. PMID: 17158929
10. Ime2 phosphorylates Sum1, a repressor of meiotic gene transcription, on Thr-306 PMID: 17198398
11. Ime2 kinase activity mediated by the C-terminal domain is required for the efficient production of normal four-spore asci. These data suggest a role for Ime2 in spore number control in S. cerevisiae. PMID: 18339400
12. The glucose sensors had only a minor role in regulating transcript levels of the two key regulators of meiotic initiation, the Ime1p transcription factor and the Ime2p kinase, but a major role in regulating Ime2p stability. PMID: 18616605
13. Ime2 is a key activator of Smk1 signaling. PMID: 19087957
14. Results show that human Cdk2 is a functional homolog for most of Ime2 functions. PMID: 19197163

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KEGG: sce:YJL106W

STRING: 4932.YJL106W