Ilp2 Antibody

1. Immunosenescence in Drosophila suggests its possible mechanisms that involve changes in insulin/IGF-1 signaling. (Review) PMID: 30134574
2. Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms PMID: 27452396
3. dPKD mediated secretion of dILP2 from neurosecretory cells during development is necessary for normal larval growth. PMID: 29247620
4. Results found that virgin females with knockout mutations of Ilp2, Ilp3 and Ilp5 show high mating success rate with higher locomotion. PMID: 26617266
5. Knockdown of the Drosophila orthologues of human T2DM risk genes, including GLIS3 and BCL11A, revealed roles of these Drosophila genes in Ilp2 production or secretion. PMID: 25101872
6. Under hypoxic conditions, Sima nuclear localization in the fat body is associated with lipid droplet aggregation and impaired lipid mobilization to oenocytes. The fat body in turn, perhaps through a secreted signal, inhibits Dilp2 secretion from the larval brain, associated with reduced insulin receptor signaling in peripheral tissues. PMID: 25541690
7. These results indicate that adiponectin receptor in insulin producing cells regulates insulin secretion and controls glucose and lipid metabolism in Drosophila melanogaster. PMID: 23874700
8. dMyc in fat body affects the release of DILP2 from the insulin producing cells. PMID: 23608455
9. show that the DILP-producing median neurosecretory cells are required to mediate nearly all of the response of lifespan and some of the response of fecundity to yeast levels PMID: 20156206
10. brain insulin-producing cells are the main systemic supply of insulin during larval growth PMID: 12004130
11. despite the correlation between reduced dilp2 mRNA levels and lifespan-extension often observed, DILP2 reduction is not sufficient to extend lifespan PMID: 19005568

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KEGG: dme:Dmel_CG8167

STRING: 7227.FBpp0076058

UniGene: Dm.2285