Ilp6 Antibody

1. it was demonstrated for the first time that insulin-like DILP6 protein in drosophila influences the level of octopamine (regulating the activity of the enzyme degrading octopamine). PMID: 29368833
2. suggest a feedback system in the interaction between juvenile hormone and DILP6 in which DILP6 negatively regulates the JH titre via an increase in the hormone degradation and a decrease in its synthesis PMID: 27823956
3. Fat body-derived Drosophila insulin-like peptide 6 induces lipid uptake in oenocytes, promoting lipid turnover during fasting and increasing starvation tolerance. PMID: 25472843
4. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. PMID: 22935001
5. Study shows that during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal; expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone. PMID: 20059956
6. Shows that Drosophila insulin-like peptide 6 (DILP6), which is structurally similar to vertebrate insulin-like growth factor (IGF), is predominantly expressed in the fat body, a functional equivalent of the vertebrate liver and adipocytes. PMID: 20059957

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KEGG: dme:Dmel_CG14049

STRING: 7227.FBpp0070390

UniGene: Dm.31063