iscR Antibody

1. findings show how an sRNA, RyhB, and a transcription factor, IscR, regulate expression of an essential gene, erpA, in E. coli PMID: 27651365
2. Authors demonstrate that in the absence of isc, IscR-dependent suf activation is essential since strains lacking both the Isc pathway and IscR were not viable unless Suf was expressed ectopically. PMID: 25266384
3. These data suggest a unique mechanism of ligand-mediated DNA site recognition, whereby metallocluster ligation relocates a protein-specificity determinant to expand DNA target-site selection, allowing a broader transcriptomic response by holo-IscR. PMID: 23644595
4. Fe-S clusters directed at the apo-NsrR and apo-IscR proteins are built on either of the two scaffolds, IscU or SufB. PMID: 23320508
5. Together, these data show how transcriptional control of iscRSUA-hscBA-fdx by [2Fe-2S]-IscR allows E. coli to respond efficiently to varying Fe-S demands. PMID: 23075318
6. a combination of ArcA and AppY antirepression of IscR function, lower levels of IscR, and weak repression by [2Fe-2S]-IscR leads to increased hyaA promoter expression under anaerobic conditions PMID: 23065979
7. These results suggest that, IscR stabilizes LexA at the cka promoter after DNA damage thus, preventing its cleavage and inactivation, and this cooperation ensures that suicidal colicin K production is switched on only as a last resort. PMID: 22812562
8. The findings presented here indicate a more general role of IscR in the regulation of Fe-S cluster biogenesis and that IscR contributes to the O(2) regulation of several promoters controlling the expression of anaerobic Fe-S proteins. PMID: 16677314
9. The iscR null mutation abolished oxidant-responsive elements binding activity in cell extracts. PMID: 16824106
10. Activation of the suf operon by IscR occurs only under conditions where Fur loses its repressor activity. PMID: 18849427

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KEGG: ecj:JW2515

STRING: 316385.ECDH10B_2698