IST2 Antibody

1. The authors show that, in BY4741 background, the lack of Ist2 results in the accumulation of higher amounts of sodium when the cells are exposed to the presence of this cation, demonstrating the importance of Ist2 for the maintenance of low intracellular levels of toxic sodium. PMID: 28199631
2. IST2 localization depends on the presence of a PM-binding domain, an intrinsically disordered linker region of sufficient length. PMID: 25409870
3. Data suggest that Btn2p, along with Btn1 and Ist2, may play a regulatory role across the cell in response to alterations in the intracellular environment. PMID: 15701790
4. Based on these observations, we suggest a local synthesis of Ist2p at cortical ER sites, from where the protein is sorted by a novel mechanism to the plasma membrane. PMID: 15911878
5. posttranslational mechanism, which leads to the concentration of Ist2--via multimerization--at ER sites, followed by direct transport to the plasma membrane PMID: 17234190
6. Results suggest that a direct interaction of the Ist2 sorting signal with lipids at the plasma membrane places Ist2 at contact sites between cortical ER and plasma membrane. PMID: 19208765
7. Data show that binding of phosphatidylinositol phosphates leads to efficient accumulation of Ist2 at domains of the cortical ER from where the protein may reach the PM independently of the function of the sec-pathway. PMID: 19453974

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KEGG: sce:YBR086C

STRING: 4932.YBR086C