Iswi Antibody

1. the role of ISWI in the hnRNPshsromega interaction PMID: 28209301
2. ISWI enables bi-directional transitions between two fundamentally different forms of chromatin. PMID: 26549447
3. Insertion of flexible linkers at strategic sites in ISWI that disrupt a power stroke does not affect nucleosome sliding. PMID: 24113208
4. In a purified system ISWI- and CHD1-type nucleosome remodelers have a clamping activity such that they not only generate regularly spaced nucleosome arrays but also generate constant spacing regardless of nucleosome density. PMID: 25733687
5. The effect of H4 tail at lysine 16 acetylation on ISWI remodelling depends on the precise nature of the substrate. PMID: 24516652
6. finding show all fundamental aspects of nucleosome-remodeling catalysis are contained within the compact ATPase domain of ISWI PMID: 23202585
7. define two new, conserved and separate regulatory regions on Drosophila ISWI, termed AutoN and NegC, which negatively regulate ATP hydrolysis (AutoN) or the coupling of ATP hydrolysis to productive DNA translocation (NegC). PMID: 23143334
8. This study revealed a novel conformation of an ISWI ATPase domain PMID: 22167269
9. Loss of ISWI causes global defects in omega speckle organization. PMID: 21637796
10. ISWI binds genes near their promoters causing specific alterations in nucleosome positioning at the level of the Transcription Start Site, and thus a role in higher eukaryote transcriptional regulation. PMID: 21448136
11. ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses. PMID: 20194965
12. results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation PMID: 20008562
13. ISWI recognizes an 'epitope' consisting of the DNA-bound H4 tail PMID: 11809876
14. Histone acetylation reduces the ability of ISWI to interact with its substrate, couteracting chromatin compaction. PMID: 11882543
15. ISWI is a 3'-5'-strand-specific, ATP-dependent DNA translocase that may be capable of forcing DNA over the surface of nucleosomes. PMID: 12612068
16. Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI PMID: 14536084
17. the roles of dom and iswi in germ line stem cell and somatic stem cell regulation PMID: 16322456
18. Site-specific acetylation of Iswi by Gcn5. PMID: 17760996
19. The chromatin remodeler Iswi directly represses Wg transcriptional targets. PMID: 18786525
20. The work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers. PMID: 18922045
21. Findings suggest that ISWI regulates higher-order chromatin structure by modulating the interaction of H1 with interphase chromosomes. PMID: 19380479

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KEGG: dme:Dmel_CG8625

STRING: 7227.FBpp0086954

UniGene: Dm.2581