Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Itgbn Polyclonal antibody

Uniprot No.

Q27591

Target Names

Itgbn

Alternative Names

Itgbn antibody; beta-nu antibody; betaInt-nu antibody; Itgbetanu antibody; CG1762 antibody; Integrin beta-nu antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Itgbn protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth.

Gene References into Functions

that integrin alphaPS3/betanu serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes. PMID: 23426364
Draper and integrin betanu cooperate in the phagocytic elimination of S. aureus by recognizing distinct cell wall components PMID: 22547074
Mutagenesis of the integrin cytoplasmic domain, within the chimera, showed the dominant-negative inhibition was not due to talin sequestration alone and that additional interactions are required. PMID: 16569666

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Integrin beta chain family

Tissue Specificity

Expression is confined to the developing midgut endoderm and its precursors during embryogenesis. In the larvae, expression is concentrated in the midgut imaginal disks. Expressed in embryonic and larval hemocytes (at protein level).

Database Links

KEGG: dme:Dmel_CG1762

STRING: 7227.FBpp0080990

UniGene: Dm.19859

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Itgbn Antibody

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