JHD2 Antibody

Code CSB-PA344439XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) JHD2 Polyclonal antibody
Uniprot No.
Target Names
JHD2
Alternative Names
JHD2 antibody; YJR119C antibody; J2035Histone demethylase JHD2 antibody; EC 1.14.11.- antibody; Jumonji/ARID domain-containing protein 2 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) JHD2 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'.
Gene References into Functions
  1. H2B Lys-123 ubiquitination blocks Jhd2 from accessing its binding site on chromatin, and thereby, we have uncovered a second mechanism by which H2B ubiquitination contributes to the trans-histone regulation of H3K4 methylation. PMID: 26451043
  2. Jhd2, an evolutionarily conserved JARID1 family H3 Lys4 demethylase, effects all states of methylated histone H3K4 within the NTS regions of rDNA, and its activity is required for the regulation of rDNA silencing in a Sir2-independent manner. PMID: 25248920
  3. the JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation PMID: 20538609
  4. A novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing. PMID: 17310254
  5. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-(lysine) K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo. PMID: 17310255
  6. the protein level of the yeast histone H3 Lys 4 (H3 K4) demethylase Jhd2/Kdm5 is modulated through polyubiquitination by the E3 ubiquitin ligase Not4 and turnover by the proteasome PMID: 19346402

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Subcellular Location
Nucleus.
Protein Families
JARID1 histone demethylase family
Database Links

KEGG: sce:YJR119C

STRING: 4932.YJR119C

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