JMJ14 Antibody

Code CSB-PA818105XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) JMJ14 Polyclonal antibody
Uniprot No.
Target Names
JMJ14
Alternative Names
JMJ14 antibody; JMJ4 antibody; PKDM7B antibody; At4g20400 antibody; F9F13.50Probable lysine-specific demethylase JMJ14 antibody; EC 1.14.11.- antibody; Jumonji domain-containing protein 14 antibody; Jumonji domain-containing protein 4 antibody; Lysine-specific histone demethylase JMJ14 antibody; Protein JUMONJI 14 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana JMJ14 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional repressor. Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a higher activity for H3K4me3 and H3K4me2 than H3K4me1. No activity on H3K9me3/2, H3K36me3/2 and H3K27me3/2. Represses FT and TSF expression to inhibit the floral transition. Binds around the transcription start site of the FT locus. Involved in the DRM2-mediated maintenance of DNA methylation, but not required for the de novo DNA methylation. Required for demethylating histone H3K4me3 at the target of RNA silencing. Together with NAC051/NAC052 and NAC050, regulates gene expression and flowering time, probably by the promotion of RNA-mediated gene silencing.
Gene References into Functions
  1. Plants defective in JMJ14 exhibit reduced Histone3 Lysine9 Lysine14 acetylation (H3K9K14Ac) levels, reduced polymerase II (Pol II) occupancy, and reduced transgene transcription. PMID: 23001035
  2. JMJ14 is specifically involved in the maintenance phase of DRM2-mediated RNA-directed DNA methylation. [Jmj14] PMID: 21052090
  3. JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing. [JMJ14] PMID: 20478993
  4. AtJmj4 and ELF6 are H3K4 demethylases directly repressing FT chromatin and preventing precocious flowering in Arabidopsis. [AtJmj4] PMID: 19946624
  5. PKDM7B is involved in H3K4 demethylation in FT and TSF chromatin, and represses expression of these genes to inhibit the floral transition. PMID: 20202164
  6. JMJ14 (At4g20400), is an active histone H3K4 demethylase and is involved in flowering time regulation. PMID: 20177424

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Subcellular Location
Nucleus, nucleoplasm. Nucleus. Note=Not detected in the nucleolus and the chromocenters.
Protein Families
JARID1 histone demethylase family
Tissue Specificity
Expressed in shoot apex, primary root tip, trichomes of young leaves, leaf vascular tissues, anther filaments and styles. Detected in inflorescences, leaves, stems, roots and siliques. Mostly expressed in floral organs, and, at low levels, in other organs
Database Links

KEGG: ath:AT4G20400

STRING: 3702.AT4G20400.1

UniGene: At.43482

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