Klp10A Antibody

1. Near atomic resolution cryo-electron microscopy structures of Drosophila melanogaster kinesin-13 KLP10A protein constructs in complex with curved tubulin protofilaments or bound to the microtubule lattice show how the kinesin-13-specific loop-2 couple ATP-hydrolysis conformational changes in the motor domain with tubulin bending and microtubule depolymerization. PMID: 29695795
2. The authors propose that klp10A functions to counteract undesirable asymmetries that may result as a by-product of achieving asymmetries essential for successful stem cell divisions. PMID: 27885983
3. In the absence of Klp10A the distribution of Drosophila pericentrin-like protein (Dplp), Sas-4 and Sak/Plk4 that are restricted in control testes to the proximal end of the centriole increase along the centriole length. PMID: 27764551
4. Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule PMID: 27074684
5. Kin-Tub-2 site enhances tubulin cross-linking and MT bundling properties of KLP10A in-vitro. Disruption of the Kin-Tub-2 site, despite not having a deleterious effect on MT depolymerization PMID: 24015286
6. Anaphase B is induced by the minus end-stabilizing protein patronin, which antagonizes the kinesin-13 depolymerase KLP10A at spindle poles. PMID: 24100293
7. These results indicate that the regulation of microtubule dynamics through KLP10A plays a critical role in restricting the length and maintaining bipolarity of the acentrosomal meiotic spindle PMID: 22865737
8. in both cultured cell lines and the testes, absence of Klp10A leads to longer centrioles that show incomplete 9-fold symmetry at their ends PMID: 22365849
9. two functionally distinct microtubule-destabilizing KinI kinesin enzymes are responsible for normal chromatid-to-pole motion in Drosophila PMID: 14681690
10. dynein, abnormal spindle protein (Asp), and KLP10A have roles in Drosophila spindle pole organization PMID: 15888542
11. This review reveals remarkable coordination between two kinesin 13 family members, KLP59C and KLP10A, in which KLP10A initiates microtubule depolymerization while KLP59C perpetuates depolymerization after its initiation. PMID: 16205125
12. Klp10A exclusively antagonises Orbit in the regulation of bipolar spindle formation and maintenance. PMID: 16723741
13. KLP10A may stabilize rather than destabilize microtubules, regulating spindle length and positioning the oocyte spindle. By altering microtubule dynamics, KLP10A could promote spindle reorientation upon oocyte activation. PMID: 18250200
14. Results suggest a model in which phosphorylation of the KLP10A motor domain provides a regulatory switch controlling the time and place of microtubule depolymerization. PMID: 19687256

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KEGG: dme:Dmel_CG1453

STRING: 7227.FBpp0073333

UniGene: Dm.130