kni Antibody

1. Phenotypic analysis of these 'in locus' mutations based on both expression of Kni protein and adult wing phenotypes, reveals novel unexpected features of L2-cis-regulatory module function including evidence for a chromosome pairing-dependent process that promotes transcription. PMID: 29274230
2. Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting prothoracicotropic hormone and TOR/S6 Kinase signaling. PMID: 24945799
3. Knirps causes local changes of histone density and acetylation, and the inhibition of activator recruitment, without affecting the recruitment of basal transcriptional machinery. PMID: 21353562
4. identifed a 1.4 kb cis-acting enhancer element from the kni locus that faithfully directs gene expression in the second longitudinal wing vein (L2) primordium PMID: 12466192
5. absence of maternal DSP1 results in A4 segmentation defects that are correlated with a diminution of the kni expression domain PMID: 12820172
6. Functional similarity of Knirps CtBP-dependent and C-terminal Binding Protein-independent transcriptional repressor activities. PMID: 12888527
7. Knirps protein is a short-range transcriptional repressor that locally inhibits activators by recruiting the CtBP co-repressor. PMID: 15128671
8. DNA-binding Gal4-CtBP fusion proteins also require NAD binding for activity, indicating that NAD plays a role in repression at a step subsequent to CtBP recruitment to the promoter PMID: 15199149

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KEGG: dme:Dmel_CG4717

STRING: 7227.FBpp0077941

UniGene: Dm.2511