Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) KRP1 Polyclonal antibody

Uniprot No.

Q67Y93

Target Names

KRP1

Alternative Names

KRP1 antibody; ICK1 antibody; At2g23430 antibody; F26B6.8Cyclin-dependent kinase inhibitor 1 antibody; Inhibitor/interactor of CDK protein 1 antibody; KIP-related protein 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana KRP1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Binds and inhibits CYCD2-1/CDKA-1 kinase complex activity. Regulates cell division which is crucial for plant growth, development and morphogenesis. Functions in turning cells from a mitotic to an endoreplicating cell cycle mode. Acts cell- and non-cell-autonomously to regulate endoreduplication by allowing S phase progression, but blocking entry into mitosis. Keeps on the one hand the plant cell cycle locally controlled, and on the other hand provides a possibility of linking cell cycle control in single cells with the supracellular organization of a tissue or an organ. May target specifically CDKA-1.

Gene References into Functions

A short motif in ICK1 plays role in ICK degradation and stability PMID: 27233081
ICK1 and ICK5 may be involved in developmental delay and that the suppressed growth under glucose treatment probably resulted from disturbed mitotic and endoreduplication cycle in autotetraploid Arabidopsis. PMID: 22476290
This work demonstrates that impeding cell cycle progression by means of ICK1/KRP1 and ICK2/KRP2 overexpression severely restricts gall development. PMID: 23574394
Arabidopsis ICK1 blocks entry into mitosis but allows S-phase progression causing endoreplication, suggesting that plant CKIs act in a concentration-dependent manner and have an important function in cell proliferation as well as in cell cycle exit. PMID: 15749764
ICK1/KRP1 localizes to different subnuclear domains, and is an unstable protein with its degradation mediated by at least two domains. PMID: 16766674
Nuclear localization of ICK1 is regulated and suggests a possible role of ICK1 in regulating the cellular distribution of CDKA. PMID: 16845478
The role of KRP1 in the plant cell cycle, and its degradation pathways, are reported. PMID: 18005227

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Subcellular Location

Nucleus, nucleoplasm. Note=Distributed in a ponctuate pattern and in heterochromatic chromocenters.

Protein Families

CDI family, ICK/KRP subfamily

Tissue Specificity

Expressed at low levels in roots, stems, leaves and flowers.

Database Links

KEGG: ath:AT2G23430

STRING: 3702.AT2G23430.1

UniGene: At.24577

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KRP1 Antibody

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