mei-1 Antibody

1. The reconstructions show that katanin cycles between open spiral and closed ring conformations, depending on the ATP occupancy of a gating protomer that tenses or relaxes interprotomer interfaces. PMID: 28783150
2. mei-1 and aspm-1 promote oocyte meiotic spindle pole assembly PMID: 24554763
3. The phosphorylation of MEI-1 may ensure temporal activation of the katanin complex during meiosis, whereas CRL3(MEL-26)-mediated degradation of both MEI-1 and its activator PPFR-1 ensure efficient katanin inactivation in the transition to mitosis. PMID: 23918937
4. MEI-1 is required for translocation of the meiosis I spindle to the oocyte cortex. PMID: 12885567
5. The BTB-containing protein MEL-26 is a component required for degradation of MEI-1 in vivo; importantly, MEL-26 specifically interacts with CUL-3 and MEI-1 in vivo and in vitro, and displays properties of a substrate-specific adaptor PMID: 13679921
6. the identification of BTB-domain protein MEL-26 and its genetic target MEI-1 as substrate-specific adaptors for C. elegans CUL-3 PMID: 13679922
7. MEI-1 is the only essential target for MEL-26, and possibly for the E3 ubiquitin ligase CUL-3, but the upstream ubiquitin ligase activating enzyme RFL-1 has additional essential targets PMID: 19361490

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KEGG: cel:CELE_T01G9.5

STRING: 6239.T01G9.5b.1

UniGene: Cel.18411