YKU80 Antibody

1. the yKu-distal portion of telomeres is bound by Rap1, which in turn reduces the potential for yKu(Yku80 and Yku70 )to mediate NHEJ. These results thus propose a solution to a long-standing conundrum, namely how to accommodate the apparently conflicting functions of Ku on telomeres. PMID: 27930670
2. Deletion of Est1 has a much greater impact on telomere lengthening in the presence of a Cdc13-Est2 fusion than deletion of YKU80, suggesting that any contribution that Ku may have in telomerase activation is minor compared to that of Est1. PMID: 24879463
3. The TORC1 signal is transduced by the Gln3/Gat1/Ure2 pathway, which controls the levels of the Ku heterodimer, a telomere regulator. PMID: 22169538
4. These findings contradict the recruitment model of Ku binding both DNA and RNA simultaneously and lead to a new model for the mechanism by which Ku's interaction with TLC1 RNA contributes to telomerase recruitment. PMID: 22365814
5. Ku must load directly onto the chromosome end in order to mediate its telomeric functions PMID: 21852961
6. The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation. [YKU80] PMID: 21441303
7. The authors show here that the essential Cdc13-Stn1-Ten1 complex is entirely dispensable for telomere protection in non-dividing cells, however, Yku and Rap1 become crucially important for this function in these cells. PMID: 20628356
8. Findings support the hypothesis that yKu and core X play a pivotal role in maintaining genome stability through nuclear architecture by mediating a defensive fold-back structure at yeast chromosome ends. PMID: 19652176
9. Findings implicate a role for both yKu and core X in stabilizing the genome against recombination events involving telomeric sequences. PMID: 19652177
10. Ku- and Esc1-dependent pathways mediate natural telomere anchoring in vivo PMID: 15014445
11. data support a model in which Ku recruits telomerase to telomeres in G1 phase when telomerase is inactive and promotes telomerase-mediated telomere lengthening in late S phase PMID: 15531893
12. yKu80 regulates the function of recombination enhancer during yeast mating type switching PMID: 16166630
13. Ku functions as a genomic gatekeeper through its crosstalk with DNA damage checkpoints PMID: 16446442
14. Mre11 functions in Rad51-independent break-induced replication (BIR), and Ku functions in Rad51-dependent BIR PMID: 17321803
15. A 'two-face' model for Ku is proposed and the divergent evolution of these faces allowed Ku's dual role in nonhomologous end-joining and telomere maintenance. PMID: 17351632
16. The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae. PMID: 18716325
17. Yku80-Dnl4 interactions are important for formation of a productive ligase-DSB intermediate. PMID: 18832348
18. Association of the Ku heterodimer with broken DNA ends inhibits recombination in mrx mutants, but not in repair-proficient cells or in other DNA repair single mutants. PMID: 18992851
19. yKu complex is associated with mating type locus HML and HMR sequences in a mating-type-specific manner. PMID: 19047366

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KEGG: sce:YMR106C

STRING: 4932.YMR106C