lz Antibody

Datasheet

Code	CSB-PA893836XA01DLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) lz Polyclonal antibody

Uniprot No.

Q9W349

Target Names

Alternative Names

lz antibody; CG1689 antibody; Protein lozenge antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) lz protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory sensilla development.

Gene References into Functions

Identification of the Doublesex protein binding sites that activate expression of lozenge in the female genital disc in Drosophila melanogaster has been reported. PMID: 28087460
Lz provides key intrinsic information to cells during the second wave of pattern formation in the developing ommatidium. PMID: 24067351
mlf participates in a positive feedback loop to fine tune the activity of the RUNX transcription factor Lozenge (LZ) during development of the crystal cells. PMID: 22411814
Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture. PMID: 20368357
Results lead to conclude that Ttk69 can either directly or indirectly repress lz gene expression to prevent the premature development of R7 precursor cells in the developing eye of Drosophila. PMID: 20003234
Yan regulates Lozenge during eye development PMID: 12111211
Lozenge is required to contribute to the repression of cell death mechanisms, creating a permissive environment for the survival of undifferentiated cells in early eye development PMID: 12690448
role in crystal cell and plasmatocyte production PMID: 14504400
Lz can trigger crystal cell development. PMID: 14657024
Lz promotes apoptosis in the eye during pupal development, in part by regulating argos and klumpfuss protein expression. PMID: 15879554
Glial cells missing (GCM)/GCM2 play a key role in controlling the size of the crystal cell population by inhibiting lz activation and maintenance PMID: 16176949
Required for serpent regulation of u-shaped. PMID: 16730345
Srp and Lz do not just specify the crystal cell lineage, but also regulate the later differentiation of these cells. PMID: 17417793
Maintenance of the crystal cell hematopoietic lineage choice and the realization of the crystal cell differentiation program rely on cooperation between RUNX factor Lozenge (Lz) and GATA factor Serpent (Srp). PMID: 17418114
Results show that the GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development. PMID: 17869239

Hide All

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in the pupal eye during programmed cell death.

Database Links

KEGG: dme:Dmel_CG1689

STRING: 7227.FBpp0071255

UniGene: Dm.2929

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Neuronal Markers and Neurodegenerative Diseases An Overview of Cell Death: Necrosis and Apoptosis NRG1: an Intriguing Therapeutic Target in Diseases Proteolysis Targeting Chimera (PROTAC): A "Revolutionary" Technology in Small Molecule Drug Discovery! DDR1: a Novel Member of the RTKs Family, a Potential Target for Tumor Therapy! Intestinal Mucosal Barrier Bodyguard --ALPi Dual Role of TNFRSF14 in Immunology CD73, What a Powerful Therapy Target in Tumor Immune Exploring Biological Landscape of Cervical Cancer: A Comprehensive Overview for Researchers TFR1 (TFRC): a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers! Protein Phosphorylation: The Dynamic Language of Cellular Regulation Microglial Markers: Insights into Microglial Activation and Function Knowledge about Transthyretin The Overview of Recombinant Antibody Glial Fibrillary Acidic Protein - Astrocyte Specific Marker Biological Activity of Proteins The Overview of Cell Viability One World, One Hope——What Can We Do about AIDS? A "trembling" Parkinson's Disease SLC39A6/ZIP6: a Key Member of Zinc Transporters, a Novel Targeting Antigen of ADC! Exploring Neurodegeneration: A Comprehensive Guide for Researchers Unraveling the Dynamic World of Histone Modifications: Implications in Gene Regulation and Disease Pathogenesis Does TNF Superfamily Inhibit Cancer or Promote Its Development? TROP2, An Important Target for Cancer Research GLP-1R: An Energy Metabolism Regulator of GPCR Family, an Effective Drug Target for Type 2 Diabetes Therapy! ANGPT2 (Ang-2): the First Bispecific Antibody for Eye Vision Loss Therapy, a Novel Target for Tumor Angiogenesis! Myosin Regulatory Light Chains (MYL12A and MYL12B): the New Functional Ligands for CD69, Potential Targets for Cardiac Disease or Tumors Research? Do You Really Know Neurons and Glia Cells in Nerve System? CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders! The Memory thief - Alzheimer's disease Tumor Necrosis Factor (TNF) The Overview of Interleukin TTR: an Important Protein of Amyloidosis, Novel Therapies are Upcoming for Rare Diseases ATTR-CM and ATTR-PN! The overview of Wnt signaling pathway What Should You Know about Exosomes? Bispecific Antibody Overview: From Definition to Application The Review of Post-translational Modifications SEMA4D/CD100: As an Important Immunoregulator to Improve Immunotherapy In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your Research Exploring Protein-Protein Interactions: A Comprehensive Guide to Understanding and Utilizing It What Are the Best Antibody Purification Methods for Your Research Needs? Glycolysis Pathway: The Essential Energy Source for Cells, Even in Low-Oxygen Conditions IL-6: A Central Factor in Cytokine Storms and a Health Alert for Infections and Diseases MSTN: A Key Target for Targeted Therapy in Muscle Diseases Interleukin-2 (IL2): The "Double-Edged Sword" of the Immune System Colony Stimulating Factor 1 (CSF1): Its Key Role in Diseases and New Progress in Targeted Therapy SEZ6: A New Therapeutic Target for Neuroendocrine Tumors with Multiple ADCs in Clinical Development Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

lz Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background