Lsd-1 Antibody

Code CSB-PA894204XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Lsd-1 Polyclonal antibody
Uniprot No.
Target Names
Lsd-1
Alternative Names
Lsd-1 antibody; CG10374Lipid storage droplets surface-binding protein 1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Lsd-1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for normal deposition of neutral lipids in the oocyte.
Gene References into Functions
  1. Knockdown of the lipid storage droplet 1 gene in the entire Drosophila melanogaster body caused lethality, indicating that Lsd1 is an essential function for viability. PMID: 27136547
  2. Lsd1 restricts the number of GSC-like cells by regulating a diverse group of genes and provide further evidence that escort cell function must be carefully controlled during development and adulthood to ensure proper germline differentiation. PMID: 24625679
  3. SIRT1, in complex with LSD1, has a role in developmental epigenetic gene repression and regulation. PMID: 21596603
  4. Phosphorylation of Lsd1 promotes a 1.7-fold activation of the main fat body lipase and demonstrates the direct link between Lsd1 phosphorylation and activation of lipolysis. PMID: 18342616
Subcellular Location
Cytoplasm. Lipid droplet. Note=Cytoplasmic and in lipid storage droplets of adipocytes of first instar larvae. Colocalizes with Lsd-2 on the surface of neutral lipid storage droplets in cells of fat bodies.
Protein Families
Perilipin family
Database Links

KEGG: dme:Dmel_CG10374

STRING: 7227.FBpp0083846

UniGene: Dm.1300

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