M2-1 Antibody

Code CSB-PA518618ZA01HXK
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Product Details

Full Product Name
Rabbit anti-Human respiratory syncytial virus B (strain B1) M2-1 Polyclonal antibody
Uniprot No.
Target Names
M2-1
Alternative Names
Matrix M2-1 (Envelope-associated 22 kDa protein), M2-1
Raised in
Rabbit
Species Reactivity
Human respiratory syncytial virus B
Immunogen
Recombinant Human respiratory syncytial virus B M2-1 protein
Immunogen Species
Human respiratory syncytial virus B (strain B1)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to poly(A)-rich sequences. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate host NF-kappa-B through association with host RELA.
Gene References into Functions
  1. an overview of the current understanding of the structure and function of HRSV M2-1, drawing on additional information derived from its structural homologues from other related viruses. PMID: 29900500
  2. M(2-1) is a highly stable, zinc binding tetramer with strong pH-dependent dissociation. PMID: 21877705
  3. epitope mapping; n-terminus has role in protein folding PMID: 15784904
  4. identified a new RSV-specific, H-2K(d)-restricted subdominant epitope in the M2 protein, M2(127-135) (amino acids 127 to 135) PMID: 17182672
Subcellular Location
Virion. Host cytoplasm. Host nucleus.
Protein Families
Pneumovirinae M2-1 protein family
Database Links

KEGG: vg:1489826

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