mab-3 Antibody

Code CSB-PA522723XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mab-3 Polyclonal antibody
Uniprot No.
Target Names
mab-3
Alternative Names
mab-3 antibody; Y53C12B.5 antibody; Protein male abnormal 3 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mab-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription factor which binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription.
Gene References into Functions
  1. MAB-3 regulates oxidative stress sensitivity by repressing transcription of ELT-2 target genes in the intestine. PMID: 20498281
  2. mab-3 is suppressed by the mutants of mes-2, mes-3, and mes-6. PMID: 12791262
  3. mab-3 is suppressed by mutants of mes-2, mes-3, and mes-6. PMID: 12791273
Subcellular Location
Nucleus.
Tissue Specificity
Expression is undetectable in hermaphrodites, but persists in males. In males, expressed in cells of the tail tip.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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