mab-5 Antibody

Code CSB-PA319860XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mab-5 Polyclonal antibody
Uniprot No.
Target Names
mab-5
Alternative Names
mab-5 antibody; C08C3.3Homeobox protein mab-5 antibody; Protein male abnormal 5 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mab-5 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation.
Gene References into Functions
  1. EGL-20 mediates an acute inhibition of anterior migration independently of BAR-1 and MAB-5, and a later, possible transcriptional response mediated by BAR-1 and MAB-5. PMID: 26863303
  2. Genes regulated by MAB-5 were enriched for those encoding secreted and transmembrane molecules that affect extracellular matrix PMID: 23642123
  3. Data show wild-type mab-5 function is necessary for normal P(9-11).p fate. PMID: 20478294
  4. role of MAB-5 during ray formation; results suggest functional specificity to be conferred by the N-terminal arm and helix I, but not helix II of the homeodomain PMID: 12538523
  5. mab-5 expression was studied in neuroblast lineage in this nematode. PMID: 12930745
  6. In the P11 lineage, a complex between MAB-5 and the Pbx homolog CEH-20 directly regulates transcription of the BH3 domain gene egl-1 to initiate programmed cell death. PMID: 16421192

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Tissue Specificity
Expressed asymmetrically in the QL neuroblast.
Database Links

KEGG: cel:CELE_C08C3.3

STRING: 6239.C08C3.3

UniGene: Cel.18387

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