marA Antibody

1. Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, the authors show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage. PMID: 29133912
2. Replacement of the MarA glutamic acid residue 89 with alanine greatly increased the marbox binding and activation of many class I promoters. PMID: 21097628
3. roles of the Escherichia coli transcriptional regulators MarA, SoxS and Rob in susceptibility to cationic antimicrobial peptides PMID: 19926649
4. A model of the ternary complex shows that alpha-CTD (carboxy-terminal domain of the alpha subunit of RNA polymerase) uses a '265-like determinant' to contact MarA at a surface distant from the DNA. PMID: 15458404
5. Data show that expression of TetD activates transcription of a subset of the SoxS/MarA/Rob regulon genes and confers resistance to redox-cycling compounds and antibiotics. PMID: 15853893
6. analysis of marA-mediated transcriptional repression of the rob promoter PMID: 16478729
7. Findings show that repression of hdeAB by MarA depends on pH, growth phase, and other regulators of hdeAB and is associated with reduced resistance to acid conditions. PMID: 18083817
8. Results describe the activation of the Escherichia coli marA/soxS/rob regulon in response to transcriptional activator concentration. PMID: 18514222
9. The authors show here that tolC has two additional strong overlapping promoters, p3 and p4, which are downstream of p1, p2 and the marbox and are activated by MarA, SoxS and Rob. PMID: 18673442

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KEGG: ecj:JW5249

STRING: 316385.ECDH10B_1662