Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MBOAT7 Polyclonal antibody

Uniprot No.

Q96N66

Target Names

MBOAT7

Alternative Names

MBOAT7; BB1; LENG4; OACT7; Lysophospholipid acyltransferase 7; LPLAT 7; 1-acylglycerophosphatidylinositol O-acyltransferase; Bladder and breast carcinoma-overexpressed gene 1 protein; Leukocyte receptor cluster member 4; Lysophosphatidylinositol acyltransferase; LPIAT; Lyso-PI acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7; h-mboa-7

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) MBOAT7 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation.

Gene References into Functions

rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis PMID: 27630043
MBOAT7 polymorphism contributes to hepatic inflammation and liver fibrosis in patients with chronic hepatitis B. PMID: 28109005
identification of six consanguineous families harboring homozygous inactivating variants in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1); subjects presented with intellectual disability frequently accompanied by epilepsy and autistic features PMID: 27616480
Report an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent. PMID: 26850495
Variants in the MBOAT7 gene is associated with alcohol-related cirrhosis. PMID: 26482880
ssSPTa is identified as an LPIAT1-interacting protein. PMID: 23510452
MBOAT5 and MBOAT7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils PMID: 18772128
reviews members of the MBOAT family PMID: 18931347
LENG4 is located in the leukocyte receptor cluster on chromosome 19. PMID: 10941842
describes the cloning of human MBOAT7 PMID: 18094042

Hide All

Involvement in disease

Mental retardation, autosomal recessive 57 (MRT57)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

Membrane-bound acyltransferase family

Tissue Specificity

Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium.

Database Links

HGNC: 15505

OMIM: 606048

KEGG: hsa:79143

STRING: 9606.ENSP00000245615

UniGene: Hs.467279

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MBOAT7 Antibody

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