Recombinant Human Lysophospholipid acyltransferase 7 (MBOAT7)

Code CSB-CF850398HU
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Source in vitro E.coli expression system
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Product Details

Target Names
Uniprot No.
Alternative Names
MBOAT7; BB1; LENG4; OACT7; Lysophospholipid acyltransferase 7; LPLAT 7; 1-acylglycerophosphatidylinositol O-acyltransferase; Bladder and breast carcinoma-overexpressed gene 1 protein; Leukocyte receptor cluster member 4; Lysophosphatidylinositol acyltransferase; LPIAT; Lyso-PI acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7; h-mboa-7
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation.
Gene References into Functions
  1. rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis PMID: 27630043
  2. MBOAT7 polymorphism contributes to hepatic inflammation and liver fibrosis in patients with chronic hepatitis B. PMID: 28109005
  3. identification of six consanguineous families harboring homozygous inactivating variants in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1); subjects presented with intellectual disability frequently accompanied by epilepsy and autistic features PMID: 27616480
  4. Report an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent. PMID: 26850495
  5. Variants in the MBOAT7 gene is associated with alcohol-related cirrhosis. PMID: 26482880
  6. ssSPTa is identified as an LPIAT1-interacting protein. PMID: 23510452
  7. MBOAT5 and MBOAT7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils PMID: 18772128
  8. reviews members of the MBOAT family PMID: 18931347
  9. LENG4 is located in the leukocyte receptor cluster on chromosome 19. PMID: 10941842
  10. describes the cloning of human MBOAT7 PMID: 18094042

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Involvement in disease
Mental retardation, autosomal recessive 57 (MRT57)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
Membrane-bound acyltransferase family
Tissue Specificity
Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium.
Database Links

HGNC: 15505

OMIM: 606048

KEGG: hsa:79143

STRING: 9606.ENSP00000245615

UniGene: Hs.467279

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