mec-6 Antibody

Code CSB-PA519039XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mec-6 Polyclonal antibody
Uniprot No.
Target Names
mec-6
Alternative Names
mec-6 antibody; W02D3.3Mechanosensory abnormality protein 6 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mec-6 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity). Interacts with degenerin channel proteins and stabilizes the channel. Plays a role in mechanosensory transduction (touch sensitivity).
Gene References into Functions
  1. MEC-6 and POML-1 interact with MEC-4 to facilitate expression and localization of MEC-4 on the cell surface. Thus MEC-6 and POML-1 act more like chaperones for MEC-4 than channel components. PMID: 26941331
  2. MEC-10, but not MEC-6, forms puncta in touch receptor neurites that colocalize with MEC-4 when MEC-4 is overexpressed in the touch receptor neurons PMID: 26324944
  3. we show that mec-6 encodes a single-pass membrane-spanning protein with limited similarity to paraoxonases; mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel PMID: 12478294
Subcellular Location
Cell membrane; Single-pass membrane protein. Cell projection, axon.
Protein Families
Paraoxonase family
Tissue Specificity
Expressed in neurons including the six touch receptors, ventral cord motor neurons, HSN, PVD, PVC, IL1, and several neurons near the nerve ring, in the anal ganglion and in the male tail sensory rays, in muscles including the body wall, vulval, intestinal
Database Links

KEGG: cel:CELE_W02D3.3

STRING: 6239.W02D3.3

UniGene: Cel.197

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