Mer Antibody

Code CSB-PA631546XA01DLU
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Mer Polyclonal antibody
Uniprot No.
Target Names
Mer
Alternative Names
Mer antibody; EMR2 antibody; CG14228Moesin/ezrin/radixin homolog 2 antibody; Ezrin-moesin-radixin 2 antibody; Merlin antibody; dMerlin antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Mer protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.
Gene References into Functions
  1. Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. PMID: 28566755
  2. Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex. PMID: 28292426
  3. Rae1 increases activation of the core kinases Hippo and Warts and plays a post-transcriptional role to increase the protein levels of the Merlin, Hippo, and Warts components of the pathway; therefore, in addition to Rae1 coordinating organ size regulation with proliferative control, we propose that Rae1 also acts in a feedback circuit to regulate pathway homeostas PMID: 27494403
  4. Sip1 facilitates the activation of Merlin as a tumor suppressor protein. PMID: 25204795
  5. These results indicate that in both Drosophila and mammals, Merlin activates Wts/Lats phosphorylation without stimulating the intrinsic kinase activity of Hpo/Mst. PMID: 24012335
  6. The result reveals role for merlin in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps. PMID: 22055343
  7. Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation PMID: 21473116
  8. The role of the functional sites of the Merlin tumor suppressor in Drosophila spermatogenesis PMID: 21254560
  9. Data demonstrate that Cdc42 and Merlin act together with Pak1 to control salivary gland lumen size. PMID: 21068057
  10. the Merlin and Lap proteins colocalized at the cortex of the wing imaginal disc cells. PMID: 20391775
  11. microtubule-dependent transport is critical for Merlin function PMID: 20368450
  12. Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin PMID: 20297651
  13. Merlin mutation leads to depression of vein clonal restriction property. This means that this gene is involved not only in the control of cell proliferation, but also in the control of cell mobility and adhesion. PMID: 20297652
  14. Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav. PMID: 20159598
  15. Merlin and Expanded they are required for proliferation arrest and apoptosis in developing imaginal discs.Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. PMID: 16341207
  16. The Drosophila Neurofibromatosis 2 (NF2) tumor suppressor ortholog Merlin (Mer)controls proliferation by regulating the abundance, localization, and turnover of cell-surface receptors. PMID: 16581517
  17. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. PMID: 17258190
  18. Our results demonstrated for the first time the mitochondrial localization of Merlin and suggest that Merlin may play a role in mitochondria formation and function during spermatogenesis. PMID: 18186933
  19. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis. PMID: 18664148
  20. Mutated Merlin phenotype shows reduced developmental time. PMID: 18687152
  21. Mer and Ex signal through the Hippo pathway in Drosophila. PMID: 19531584

Show More

Hide All

Subcellular Location
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane. Note=Membrane-associated, adherens junctions and endocytic compartments. Cytoplasmic, punctate.
Tissue Specificity
Expressed predominantly in the germline. Expressed in the developing oocyte from stage 6 to the end of oogenesis and in the apical ends of follical cells from stage 10. Ubiquitous expression throughout embryogenesis with enhanced expression in mesoderm of
Database Links
CUSABIO guaranteed quality
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1