Recombinant Drosophila melanogaster Moesin/ezrin/radixin homolog 2 (Mer), partial

1. Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. PMID: 28566755
2. Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex. PMID: 28292426
3. Rae1 increases activation of the core kinases Hippo and Warts and plays a post-transcriptional role to increase the protein levels of the Merlin, Hippo, and Warts components of the pathway; therefore, in addition to Rae1 coordinating organ size regulation with proliferative control, we propose that Rae1 also acts in a feedback circuit to regulate pathway homeostas PMID: 27494403
4. Sip1 facilitates the activation of Merlin as a tumor suppressor protein. PMID: 25204795
5. These results indicate that in both Drosophila and mammals, Merlin activates Wts/Lats phosphorylation without stimulating the intrinsic kinase activity of Hpo/Mst. PMID: 24012335
6. The result reveals role for merlin in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps. PMID: 22055343
7. Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation PMID: 21473116
8. The role of the functional sites of the Merlin tumor suppressor in Drosophila spermatogenesis PMID: 21254560
9. Data demonstrate that Cdc42 and Merlin act together with Pak1 to control salivary gland lumen size. PMID: 21068057
10. the Merlin and Lap proteins colocalized at the cortex of the wing imaginal disc cells. PMID: 20391775
11. microtubule-dependent transport is critical for Merlin function PMID: 20368450
12. Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin PMID: 20297651
13. Merlin mutation leads to depression of vein clonal restriction property. This means that this gene is involved not only in the control of cell proliferation, but also in the control of cell mobility and adhesion. PMID: 20297652
14. Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav. PMID: 20159598
15. Merlin and Expanded they are required for proliferation arrest and apoptosis in developing imaginal discs.Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. PMID: 16341207
16. The Drosophila Neurofibromatosis 2 (NF2) tumor suppressor ortholog Merlin (Mer)controls proliferation by regulating the abundance, localization, and turnover of cell-surface receptors. PMID: 16581517
17. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. PMID: 17258190
18. Our results demonstrated for the first time the mitochondrial localization of Merlin and suggest that Merlin may play a role in mitochondria formation and function during spermatogenesis. PMID: 18186933
19. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis. PMID: 18664148
20. Mutated Merlin phenotype shows reduced developmental time. PMID: 18687152
21. Mer and Ex signal through the Hippo pathway in Drosophila. PMID: 19531584

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KEGG: dme:Dmel_CG14228

STRING: 7227.FBpp0074523